EVALUATION OF ANTI-ULCER ACTIVITY IN ETHANOLIC EXTRACT OF WEDELIA TRILOBATA (L.)A.HITCHC.

Aim of the study: The aim of this research was to investigate the phytochemical profile and evaluation of Anti-ulcer activity of ethanolic extract of Indian Medicinal plant of Wedelia trilobata (L.)A.Hitchc. Materials and methods: Qualitative phytochemical analysis for their phytoconstituents. Ethanol was used to extract the crude bio active compound from whole Wedelia trilobata (L.)A.Hitchc plant. Phenolic derivative were isolated from the ethanolic extract of Wedelia trilobata (L.)A.Hitchc by using suitable solvent system. The Antiulcer activity of Wedelia trilobata (L.)A.Hitchc extract were measured by Pylorus ligated induced ulcer model in rats. Result: Qualitative phytochemical analysis showed phenolic compounds, Flavonoids, Glycosides, carbohydrates and tannins.In-vivo anti-ulcer activity in rats were studied using 100 and 200mg/kg, p.odoses ofWedelia trilobata (L.)A.Hitchc. The percentage of protection were significantly found to be increased, with EEWT at dose of 100mg/kg and 200mg/kg (ip). Conclusion: Overall results the study proved that Wedelia trilobata (L.)A.Hitchc possessed potential components involving in anti -ulcer treatment significantly attenuated the various types of ulcer and also increased healing of wound and protection level.